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NASA Spaceline Current Awareness List #991 18 March 2022 (Space Life Science Research Results)

NASA Spaceline Current Awareness List #991 18 March 2022 (Space Life Science Research Results)

Status Report
From: Spaceline
Posted: Friday, March 18, 2022


Call for articles to cite in the weekly lists: Authors at NASA Centers and NASA PIs—do you have an article that has recently published or will publish in the upcoming weeks within a peer-reviewed journal and is in the scope of space life sciences? If so, send it our way! Send your article to the email address mentioned above. Articles received by Wednesday will appear within that week’s list—articles received after Wednesday will appear the following week.


Papers deriving from NASA support:



Yerukala Sathipati S, Tsai MJ, Shukla SK, Ho SY, Liu Y, Behesthi A.

MicroRNA signature for estimating the survival time in patients with bladder urothelial carcinoma.

Sci Rep. 2022 Mar 9;12:4141.

Note: This article may be obtained online without charge.

Journal Impact Factor: 4.380

Funding: A. Behesthi is affiliated with NASA Ames Research Center.



Clark C, Rivas E, Gonzales JU.

Six nights of sleep extension increases regional cerebral oxygenation without modifying cognitive performance at rest or following acute aerobic exercise.

J Sleep Res. 2022 Mar 9;e13582. Online ahead of print.

Journal Impact Factor: 3.981

Funding: E. Rivas is affiliated with NASA Johnson Space Center.



Leehan JD, Nicholson WL.

Environmental dependence of competitive fitness in rifampin-resistant rpoB mutants of Bacillus subtilis.

Appl Environ Microbiol. 2022 Mar 8;88(5):e0242221.

PI: W.L. Nicholson

Note: From the abstract: “Microbial resistance to antibiotics is a growing threat to public health across the world. Historically, resistance to antibiotics has been associated with reduced fitness. A growing body of evidence indicates that resistance to rifampin, a frontline antibiotic used to treat mycobacterial and biofilm-associated infections, may increase fitness given an appropriate environment even in the absence of the selective antibiotic. Here, we experimentally confirm this phenomenon by directly comparing the fitness of multiple rifampin-resistant mutants of Bacillus subtilis in rich LB medium and an asparagine minimal medium.”

Journal Impact Factor: 4.792

Funding: “NNX14AT38G/NASA/NASA/United States; FLA-MCS-005500/U.S. Department of Agriculture (USDA); FLA-MCS-006066/U.S. Department of Agriculture (USDA).”



Bairamian D, Sha S, Rolhion N, Sokol H, Dorothée G, Lemere CA, Krantic S.

Microbiota in neuroinflammation and synaptic dysfunction: A focus on Alzheimer’s disease.

Mol Neurodegener. 2022 Mar 5;17:19. Review.

PI: C.A. Lemere

Note: This article may be obtained online without charge.

Journal Impact Factor: 14.195

Funding: “Sorbonne Université and Institut National de la Santé et de la Recherche Médicale (INSERM) to D.B.; Centre National pour la Recherche Scientifque (CNRS) to S.K.; Centre de Recherche Saint Antoine (CRSA) to S.K. and N.R.; France Alzheimer (MicAD) and Fondation Alzheimer (MicIAD) to S.K; and NIH/NIA RF1 AG060057 and NASA 80NSSC18K0810 to C.A.L.”



Pramanik A, Sharma PC, Patibandla S, Gao Y, Ruppa-Kasani V, Goli J, Kumar A, Chatterjee A, Sinha SS, Bates JT, Bierdeman MA, Tandon R, Ray PC.

Blocking SARS-CoV-2 Delta variant (B.1.617.2) spike protein receptor-binding domain binding with the ACE2 receptor of the host cell and inhibiting virus infections using human host defense peptide-conjugated graphene quantum dots.

ACS Omega. 2022 Mar 8;7(9):8150-7.

PI: R. Tandon

Note: This article may be obtained online without charge.

Journal Impact Factor: 3.512

Funding: “P.C.R. thanks NSF-RAPID grant no. DMR-2030439 and NSFPREM grant no. DMR-1826886 for their generous funding. We also thank NIH-NIMHD grant no. 1U54MD015929-01 for the bioimaging core facility. R.T. is supported by NASA award (80NSSC19K1603) and COVID-19 funds from the University of Mississippi Medical Center.”



Stierhof J, Kühn S, Winter M, Micke P, Steinbrügge R, Shah C, Hell N, Bissinger M, Hirsch M, Ballhausen R, Lang M, Gräfe C, Wipf S, Cumbee R, Betancourt-Martinez GL, Park S, Niskanen J, Chung M, Porter FS, Stöhlker T, Pfeifer T, Brown GV, Bernitt S, Hansmann P, Wilms J, Crepso López-Urrutia JR, Leutenegger MA.

A new benchmark of soft x-ray transition energies of Ne, CO2, and SF6: Paving a pathway towards ppm [part per million] accuracy.

Eur Phys J D. 2022 Mar 1;76:38.

Note: This article may be obtained online without charge.

Journal Impact Factor: 1.425

Funding: “Financial support was provided by theMax-Planck-Gesellschaft (MPG) and Bundesministerium f¨ur Bildung und Forschung (BMBF) through project 05K13SJ2. We thank HZB for the allocation of synchrotron radiation beamtime at BESSY II. C.S. acknowledges the support by an appointment to the NASA Postdoctoral Program at the NASA Goddard Space Flight Center, administered by Universities Space Research Association under contract with NASA, by the Lawrence Livermore National Laboratory (LLNL) Visiting Scientist and Professional Program Agreement No. VA007036 and VA007589, and by MPG. Work by UNIST was supported by the National Research Foundation of Korea (No. NRF-2016R1A5A1013277). Work by LLNL was performed under the auspices of the U.S. Department of Energy under Contract No. DE-AC52-07NA27344 and supported by NASA grants to LLNL. M.A.L. and F.S.P. acknowledge support from NASA’s Astrophysics Program. Work by G.B. was supported by a NASA Space Technology Research Fellowship. Work by R.C. was supported by NASA under award number 80GSFC21M0002 and by an appointment to the NASA Postdoctoral Program at the NASA Goddard Space Flight Center. Work by M.W. was supported by the ERASMUS+traineeship program.”





Other papers of interest:



Glukhikh DO, Naumov IA, Schoenmaekers C, Kornilova LN, Wuyts FL.

The role of different afferent systems in the modulation of the otolith-ocular reflex after long-term space flights.

Front Physiol. 2022 Mar 14;13:743855.



Karpinskaia VY, Pechenkova EV, Zelenskaya IS, Lyakhovetskii VA.

Vision for perception and vision for action in space travelers.

Front Physiol. 2022 Mar 11;13:806578.

Note: From the introduction: “In this opinion paper, we will briefly review the facts that are potentially relevant for predicting alterations in the ventral and dorsal pathways during the actual spaceflight and in ground-based microgravity analogs. We will also discuss the idea that the dorsal and ventral streams may be affected differently during a microgravity-stimulated recalibration of sensorimotor coordination.” This article and the article above (Glukhikh et al.) are part of Research Topic “Brains in Space: Effects of Spaceflight on the Human Brain and Behavior” ( This article may be obtained online without charge.



Guibaud A, Legros G, Consalvi J-L, Torero J.

Fire safety in spacecraft: Past incidents and Deep Space challenges.

Acta Astronaut. 2022 Mar 12. Review. Online ahead of print.



Smirnov NN.

Space flight safety: Past and future.

Acta Astronaut. 2022 Mar 11. Online ahead of print.



Ohira T, Kawano F, Goto K, Kaji H, Ohira Y.

Responses of neuromuscular properties to unloading and potential countermeasures during space exploration missions.

Neurosci Biobehav Rev. 2022 Mar 10;104617. Review. Online ahead of print.

Note: From the abstract: “We reviewed the responses of the neuromuscular properties of mainly the soleus and possible mechanisms. Sensory nervous activity in response to passive shortening and/or active contraction, associated with plantar-flexion or dorsi-flexion of the ankle joints, may play an essential role in the regulation of muscle properties. Passive shortening of the muscle fibers and sarcomeres inhibits the development of tension, electromyogram (EMG), and afferent neurogram. Remodeling of the sarcomeres, which decreases the total sarcomere number in a single muscle fiber causing recovery of the length in each sarcomere, is induced in the soleus following chronic unloading. Although EMG activity and tension development in each sarcomere are increased, the total tension produced by the whole muscle is still less owing to the lower sarcomere number. Therefore, muscle atrophy continues to progress.”



Ji G, Chang H, Yang M, Chen H, Wang T, Liu X, Lv K, Li Y, Song B, Qu L.

The mitochondrial proteomic changes of rat hippocampus induced by 28-day simulated microgravity.

PLoS One. 2022 Mar 10;17(3):e0265108.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Mezentseva LV, Dudnik EN, Nikenina EV.

Effect of hypoxia on the stability of microcirculation parameters in the temporal head regions of humans.

Hum Physiol. 2022 Mar 5;48:94-101.

Note: From the abstract: “The purpose of this study was to compose a mathematical model, allowing to assess the stability of MCR [microcirculation] system under external influences. Short-term hypoxia was used as the external influence.” This article may be obtained online without charge.



Simon Á, Tozar T, Smarandache A, Boni M, Stoicu A, Dowson A, van Loon J, Pascu ML.

Stability studies of UV laser irradiated promethazine and thioridazine after exposure to hypergravity conditions.

Molecules. 2022 Mar 7;27(5):1728.



Stasko JT, Hammer CG, Culberson WS.

The effect of mouse size on dose from an X-Rad320 irradiator.

Radiat Res. 2022 Mar 8. Online ahead of print.



Ding L, Sishc BJ, Polsdofer E, Yordy JS, Facoetti A, Ciocca M, Saha D, Pompos A, Davis AJ, Story MD.

Evaluation of the response of HNSCC [head and neck squamous cell carcinoma] cell lines to γ-rays and 12C ions: Can radioresistant tumors be identified and selected for 12C ion radiotherapy?

Front Oncol. 2022 Feb 25;12:812961.



Furusawa Y, Kondo T, Tachibana K, Feril LBJ.

Ultrasound-induced DNA damage and cellular response: Historical review, mechanisms analysis, and therapeutic implications.

Radiat Res. 2022 Mar 11. Review. Online ahead of print.



He W, Zhang Z, Yang W, Zheng X, You W, Yao Y, Yan J, Liu W.

Turning milk into pro-apoptotic oral nanotherapeutic: De novo bionic chiral-peptide supramolecule for cancer targeted and immunological therapy.

Theranostics. 2022 Feb 21;12(5):2322-34.

Note: This article may be obtained online without charge.



Lamber EP, Guicheney P, Pinotsis N.

The role of the M-band myomesin proteins in muscle integrity and cardiac disease.

J Biomed Sci. 2022 Mar 7;29(1):18. Review.

Note: This article may be obtained online without charge.



Rozhkov SV, Sharlo KA, Shenkman BS, Mirzoev TM.

The role of glycogen synthase kinase-3 in the regulation of ribosome biogenesis in rat soleus muscle under disuse conditions.

Int J Mol Sci. 2022 Mar 2;23(5):2751.

Note: Hindlimb unloading study. This article is part of Special Issue “Advances in Skeletal Muscle Function and Metabolism” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.



Yoshihara T, Takaragawa M, Dobashi S, Naito H.

Losartan treatment attenuates hindlimb unloading-induced atrophy in the soleus muscle of female rats via canonical TGF-β signaling.

J Physiol Sci. 2022 Mar 9;72:6.

Note: Hindlimb unloading study. This article may be obtained online without charge.



Zakharova I, Saaya S, Shevchenko A, Stupnikova A, Zhiven’ M, Laktionov P, Stepanova A, Romashchenko A, Yanshole L, Chernonosov A, Volkov A, Kizilova E, Zavjalov E, Chernyavsky A, Romanov A, Karpenko A, Zakian S.

Mitomycin-treated endothelial and smooth muscle cells suitable for safe tissue engineering approaches.

Front Bioeng Biotechnol. 2022 Mar 11;10:772981.

Note: This article may be obtained online without charge.



Choi JUA, Kijas AW, Lauko J, Rowan AE.

The mechanosensory role of osteocytes and implications for bone health and disease states.

Front Cell Dev Biol. 2021 Feb 21;9:770143. Review.



Oršolić N, Nemrava J, Jeleč Ž, Kukolj M, Odeh D, Jakopović B, Jazvinšćak Jembrek M, Bagatin T, Fureš R, Bagatin D.

Antioxidative and anti-inflammatory activities of chrysin and naringenin in a drug-induced bone loss model in rats.

Int J Mol Sci. 2022 Mar 6;23(5):2872.

Note: This article is part of Special Issue “The Role of Natural Compounds in Osteoblastic and Osteoclastic Cells” ( Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.



Xu Y, Hirata E, Iizumi Y, Ushijima N, Kubota K, Kimura S, Maeda Y, Okazaki T, Yokoyama A.

Single-walled carbon nanotube membranes accelerate active osteogenesis in bone defects: Potential of guided bone regeneration membranes.

ACS Biomater Sci Eng. 2022 Mar 8. Online ahead of print.

Note: From the abstract: “In this study, we developed a CNT-based [carbon nanotube-based] membrane for GBR [guided bone regeneration] exhibiting high strength to provide a space for bone formation and provide cellular shielding to induce osteogenesis.”



Zhang JA, Lam PH, Beretov J, Murrell GA.

A review of bone grafting techniques for glenoid reconstruction.

Shoulder Elbow. 2022 Apr;14(2):123-34. Review.



Carneiro ER, Azoubel LA, Dias RC, Dias CJ, Sá ES, Brito DA, Salgado Filho N, Santos EF, Rocco JH, Mostarda CT, Bernardo Filho M.

Correlation of sleep quality and cardiac autonomic modulation in hemodialysis patients.

Sleep Sci. 2022 Jan-Mar;15(Spec 1):59-64.

Note: This article may be obtained online without charge.



Shi J, Tong R, Zhou M, Gao Y, Zhao Y, Chen Y, Liu W, Li G, Lu D, Meng G, Hu L, Yuan A, Lu X, Pu J.

Circadian nuclear receptor Rev-erbα is expressed by platelets and potentiates platelet activation and thrombus formation.

Eur Heart J. 2022 Mar 10. Online ahead of print.

Note: From the abstract: “Adverse cardiovascular events have day/night patterns with peaks in the morning, potentially related to endogenous circadian clock control of platelet activation. Circadian nuclear receptor Rev-erbα is an essential and negative component of the circadian clock. To date, the expression profile and biological function of Rev-erbα in platelets have never been reported.”



Kozhina GV, Levik YS, Popov AK, Smetanin BN.

Maintaining an upright posture with different sizes of the object providing visual feedback on rigid and compliant supports.

Hum Physiol. 2022 Mar 5;48:1-12.

Note: From the abstract: “This review presents an update of available literature on the hindlimb unloading model.”


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